0% that included parallel groups, and 9. Sep 27, 2017 · Why is it so difficult to conduct randomized controlled clinical trials in nephrology? Dr Desai explores the possible reasons presented at the Kidney Disease: Improving Global Outcomes conference. Diseases of the Cardiovascular System, Diseases of the Kidney & Urinary Tract, Genetics - Adult Genetic Determinants of Aneurysms in Autosomal Dominant Polycystic Kidney Disease Principal Investigator: Stefan Somlo. com with the trial name, link, and why you think it is a landmark paper! Or use the form below: Welcome to Landmark Trials Where we collect the most impactful research within the fields of Internal Medicine Finding the evidence Evidence-based medicine is the best way to practice healthcare in our modern May 25, 2024 · K. 2%) pediatric cardiology []. metabolic bone disease and hypertension) are Jul 15, 2020 · Here, we report the results of a multinational, randomized, open-label, controlled trial (STARRT-AKI [Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Dec 9, 2013 · Of 40,970 trials overall, 1,054 (2. Yu and OthersN Engl J Med 2024;390:1895-1904. Jan 17, 2024 · The Delphi technique is recommended by the Core Outcome Measures in Effectiveness Trials (COMET) initiative to establish consensus on critically important outcomes for trials . In this Review, Owen Lyons discusses the diagnosis, epidemiology and pathophysiology of three sleep disorders that commonly affect patients with chronic Randomized Controlled Trials as Topic*. As is the case with many ailments, early detection leads to the best treatment. At the clinical level, U. ”. 05) were included and the Fragility Index was calculated. diabetes and autoimmune disease) and systemic problems that occur as a result of kidney problems (e. 78 to 0. This sum is expected to cover the individual fellow's salary (not to exceed $65,000 Jan 2, 2024 · Multiple factors may contribute to this delay but one of the most important, which requires profound analysis, is clinical inertia. As consensus was reached by Round 2 in prior Delphi survey studies [ 12–14 ] we conducted two rounds, with additional rounds if required. Fortunately, AKF has been keeping tabs on these headlines for you. This study was a double-blind, placebo-controlled Feb 10, 2020 · The Standardized Outcomes in Nephrology–Hemodialysis (SONG-HD) initiative has established CVD as a core outcome domain for clinical trials in HD (as well as mortality, vascular access and fatigue) [11, 13, 14]. Conducting a successful prevention trial is, however, especially challenging. it is important to image the renal artery in its entirety from the origin to the kidney Sep 24, 2020 · The independent data monitoring committee recommended stopping the trial because of efficacy. By Meredith Deeley. Vascular access function was considered the most important outcome (mean score 7. Alongside clinical outcomes relating to allograft loss Feb 4, 2023 · Within the various pediatric subspecialties, there are great differences in clinical trials by subspecialty. Diseases of the Digestive Nov 7, 2017 · Patient-reported outcomes may also be identified in core outcome sets—defined as an agreed minimum set of outcomes that should be reported in all trials, because they are explicitly identified to be critically important by all stakeholders (i. 13, 15, 21, 23 Furthermore, it is important to acknowledge the inequities and disparities faced by historically and socially marginalized groups with regards to kidney disease. Nephrology trials, compared Prevention trials are appealing, because the timing of the insult leading to AKI is known. Best practices for the design of clinical trials for behavioral interventions draw upon human-centered design. 5 days ago · Systemic conditions that affect the kidneys (e. General Nephrology Trials; Trial Name Sponsor Summary Details Study Coordinator; Sparsentan TVTX-RE021-20: Travere: A phase 2 study to learn how safe and effective sparsentan in combination with sodium glucose cotransporter-2 (SGLT2) in adults with immunoglobulin a nephropathy. 2%) in the May 12, 2020 · Cardiovascular disease (CVD) affects more than two-thirds of patients receiving hemodialysis and is the leading cause of death in this population, yet CVD outcomes are infrequently and inconsistently reported in trials in patients receiving hemodialysis. 22,44-46 The Standardized Outcomes in Nephrology (SONG) initiative was recently formed to establish core outcomes across the full spectrum of chronic kidney disease with an initial focus on hemodialysis. Hypertension TARGET BP I Clinical Trial (TARGET BP I) Principal Investigator: Carlos Mena-Hurtado. Advances in Oct 2, 2013 · Furthermore, the majority of trials in nephrology have been small, single-center studies: in a recent evaluation of RCTs in nephrology, 62% of the trials had <100 participants and only 1. Landmark Trials in Peritoneal Dialysis Adequacy: A 3-Minute Read June 12, 2019 Peritoneal dialysis (PD) treatment began much earlier than hemodialysis but was not successful due to the many complications associated with it and the difficulties with access to the peritoneal cavity. The meeting began with plenary talks that aimed to identify the key themes fordiscussion related to trial design (including the specific topics of how to measure kidney and nonkidney outcomes) and trial execution before 4 breakout groups considered the key issues in detail. New effective drugs in nephrology should be celebrated and shouted from the rooftops, thus it is fitting that the AURORA trial landed in the 8th spot this year for Top Nephrology Stories. 0025) vs. The final stage identified a set of “core outcomes” that were “critically important to all stakeholder groups,” and the authors recommend that these be “reported in all [glomerular disease] trials. These patient-reported outcome measures (PROMs) have the ability to provide clinicians, researchers, and policymakers with valuable insights into patients’ symptoms and experiences that are unable to be . Dec 20, 2023 · Basic discovery and clinical trials in diabetic kidney disease (DKD) have continued to be reported in 2023 despite the disruption of research activity by COVID-19 in recent years. BMC Nephrology 2024 25 :157. ISN-ACT calls on investigators and interested individuals to join the initiative to generate more high-quality clinical trials and studies in Oct 2, 2013 · An important goal of the AKTN is membership of a global clinical trials consortium consisting of multiple clinical trial networks that connect in order to (1) identify international research and clinical priorities, (2) provide a larger pool of renal patients available for trials, and (3) avoid duplication of research trials and development of information provided in trial protocols and subse-quently increase trial quality in clinically relevant ways. 8 INSERM U1246, Tours, France. The burden of symptoms and impaired quality of life in CKD may be compounded by comorbidities and treatment side effects. post by Michelle Rheault @rheault_M. Most nephrology trials were randomized (72. A multipronged approach is required to improve study conduct and help all stakeholders to better understand the ways in which high-quality clinical trials improve patient care. Aug 24, 2022 · These studies were associated with improved outcomes, including assessment, work up and listing, which support their use across renal programs. Important dates for Kidney Week 2024. Thus, despite an increasing body of literature that these novel biomarkers are important predictors of adverse clinical outcomes, 16 they cannot be endorsed at this time as primary kidney end points for AKI trials, though their measurement as secondary end points or in early phase studies should continue and will undoubtedly add to our Jun 9, 2016 · The Need for Clinical Trials in CKD. The study was initially planned to recruit 760 patients but had to a scientific workshop to discuss these questions focusing on clinical trial design in early stages of common causes of CKD. The blood flowing through this system is anticoagulated with heparin using a syringe pump and then moves on to a two-channel pump that alternately propels blood and Jan 23, 2024 · The purpose of a clinical trial could be to study a medicine, a therapy, or a method of preventing or detecting a disease. Building on important mechanistic discoveries about Aug 13, 2022 · Over 90 people representing a range of stakeholders including faculty experts in clinical trials, nephrology, cardiology and endocrinology, patient advocacy organizations, patients, payors, health economists, regulators, and policy makers were invited for a virtual meeting held December 14-17, 2020. 2, 79% Apr 7, 2017 · An important, albeit often overlooked, reason for the lack of innovation, randomized clinical trials, and new therapies in kidney disease is the lack of qualified biomarkers and kidney-specific drug development tools that could serve as either validated or reasonably likely surrogate endpoints in clinical studies. 6%) were classified as nephrology. Apr 22, 2020 · Vesico-ureteral reflux (VUR) has long been recognized as associated with urinary tract infections (UTIs), renal scarring, and chronic kidney disease (CKD). Despite the increasing importance of graphical illustrations and visual data in clinical trials, there remains an absence of evidence in clinical trial methodological research to guide optimal use. 1. The Standardized Outcomes in Nephrology – Kidney Transplantation (SONG-Tx) was initiated in 2015 and is focused on developing core outcome domains (ie, what to measure) for all trials in kidney transplantation. -H. New Clinical Trials for Renal Impairment / Chronic Kidney Disease. 2 million people die from chronic kidney disease (CKD) every year. 9 Nuffield Department of Population Health, University of Oxford, Medical Research Council Population Health Research Unit, Clinical Trial Service Unit and Epidemiological Studies Unit, Oxford, UK. Over a median of 2. News & World Report has ranked nephrology care here among the top 50 programs in the country. Aug 31, 2023 · For example, the PrevAKI trials 11,12 only enrolled patients with evidence of kidney stress following cardiac surgery (detected by increased TIMP2*IGFBP7 levels (markers of renal stress)). Another limitation of this study is the limited generalizability, because almost all patients recruited were surgical patients. Due to the seriousness of renal impairment it is an important condition to study. Aug 1, 2017 · Increasing the number of large, important, and relevant clinical trials will require a culture shift within the nephrology community. 2023 was a big year for the kidney disease research and it can be challenging to keep up with it all. May 25, 2022 · Our findings suggest that the choice of graphical illustrations is an important source of ORB in contemporary nephrology clinical trials. Randomized controlled clinical trials (RCTs) have traditionally been regarded as an official paradigm in the evolution of treatments in the medical field. Jul 1, 2015 · Randomized controlled trials (RCTs) are important tools for evidence-based health care decisions. Most nephrology trials were for treatment (75. Oct 27, 2023 · Our analysis has several important findings: Male participants account for most (62%) of the trial participants overall and across multiple nephrology trial categories, with the exception of GN trials in which women were enrolled at marginally higher rates than men. The excitement around the CREDENCE overshadowed another important publication, that of the SONAR trial. CKD doubles a person’s risk for hospitalization and is a leading cause of death globally. Sep 3, 2019 · Tools that measure patients’ experiences and perceptions of disease are increasingly being recognized as important components of a multidisciplinary personalized approach to care. 7%), with very few diagnostic, screening, or health services research studies. Recent clinical trials have tested novel potential therapies for May 19, 2022 · Basket and umbrella trials—or more commonly, platform trials—are clinical trial design innovations that assess the effects of multiple interventions simultaneously using adaptive designs and Bayesian statistical comparisons. 4%) or prevention (15. 86; 95% CI 0. Oct 10, 2019 · In this era of complex research governance and burdensome regulation, innovations in trial conduct to enable large-scale invitation, better adherence and low-cost follow-up may be more important than innovations in trial design. RAS inhibitors were defined as ACEi or ARB. In a phase 3 trial in which over 370 patients with an FSGS lesion on kidney biopsy or a genetic Oct 1, 2020 · 7 Department of Nephrology-Hypertension, Dialysis, Renal Transplantation, Tours Hospital, Tours, France. January 10, 2024. It is, therefore, important that they be conducted and reported with the highest possible standards. 4% that were crossover trials. Patients with CKD are up to 10 times more likely to die prematurely than progress to kidney failure requiring kidney replacement therapy. As part of the Standardised Outcomes in Nephrology-Haemodialysis (SONG-HD) initiative, we convened a consensus workshop to discuss the More widespread application of the streamlined clinical trial approach such as platform studies and metatrials has the potential to empower the nephrology community to address important questions in areas of practice for which strong clinical trial evidence is often lacking such as chronic dialysis, glomerular disease, and long-term transplant Aug 1, 2019 · The survey was completed by 873 participants [224 (26%) patients/caregivers and 649 (74%) health professionals] from 58 countries. Here, the authors discuss how innovations in trial design and conduct could help achieve the goal of conducting a May 21, 2024 · Trial of sparsentan in focal segmental glomerulosclerosis (December 2023) Patients with focal segmental glomerulosclerosis (FSGS) are commonly treated with renin-angiotensin system (RAS) inhibitors to reduce proteinuria and stabilize kidney function. The aim of this study was to evaluate the reporting quality of the RCTs published in nephrology urology monthly journal and to examine whether Jul 5, 2022 · 05 July 2022. In the second half of the past century, significant progress has been made in understanding principles of causal inference and in statistical techniques underlying the proper planning and analysis of interventional trials. Formulating the trial question. Oct 29, 2022 · 28. Division faculty members care for patients Nov 4, 2022 · EMPA-KIDNEY is the first SGLT2 inhibitor CKD trial to demonstrate a significant reduction in all-cause hospitalizations (14%) (HR; 0. The RENAL-AF trial randomized patients on maintenance dialysis with AF to receive warfarin or standard dose apixaban (5 mg twice daily), unless a criterion for dose reduction was present, and was designed as a non-inferiority safety trial for clinically significant bleeding . Study designs included 24. Jun 13, 2023 · With increased attention to patient activation and SDM in nephrology, Wong’s study highlights important questions about designing and testing interventions to improve education and decision-making for patients with advanced CKD. Approximately 90 people representing a range of key stakeholders including faculty experts in clinical trials, nephrology and other relevant topic areas, patients, payers, health economists, regulators Apr 17, 2019 · All of these trials had limitations of short time frames, high (29% average) crossover rate, and small cohorts that may have lacked power to adequately determine differentiation. gov, 5035 (7%) trials involved children in the following areas: 1176 (23%) pediatric infectious disease, 664 (13%) pediatric mental health, 346 (7%) pediatric hematology/oncology, and 213 (4. AKI is an important public health issue. Jan 6, 2023 · STOP ACEi ( Bhandari et al. 7% of the The ISN-Advancing Clinical Trials (ISN-ACT) is an ISN initiative to encourage existing infrastructures within ISN to improve the global nephrology community’s participation in clinical trial research. The pioneering PIVOTAL trial, one of the largest renal clinical trials undertaken exclusively in the UK, and co-ordinated by Kidney Research UK has delivered a new set of results. Until then, it behooves us all in the nephrology community to improve trial and protocol reporting so that we can Dec 20, 2023 · Nature Reviews Nephrology - Several successfully completed clinical trials of novel therapies in glomerular disease were reported in 2023. 17 Having completed an international Delphi survey 34 to identify critically important outcome domains by all stakeholder groups, a consensus workshop was convened for patients Dec 17, 2021 · In 2021, key studies demonstrated the safety of renin–angiotensin blockade in patients with kidney failure and COVID-19, and provided new data on the therapeutic potential of soluble angiotensin Jan 10, 2024 · Nine kidney disease research breakthroughs from 2023. Frontiers has organized a series of Research Topics to highlight the latest Increasing the number of large, important, and relevant clinical trials will require a culture shift within the nephrology community. 19 More transparent and publicly available pro-tocols hopefully will translate to better trials. Jun 4, 2024 · Sleep disorders in chronic kidney disease. A lot has been learned about the kidney and diseases that can adversely affect it through nephrology clinical studies. 4 years, a primary outcome event occurred in 197 of 2152 participants (9. 9% that included a single study group, 64. In this article in the series on artificial intelligence in medicine, the authors explore how human values influence the outputs of large Oct 31, 2019 · The field of nephrology has conducted fewer trials than other medical specialties. Again, the goal was to identify outcomes most relevant to all glomerular diseases. Insights in Pediatric Nephrology: 2022. 1 As a result, the randomized controlled trial (RCT) has become the gold standard tool for proving the efficacy and safety of The International Study of Kidney Disease in Children (ISKDC), begun in 1966, conducted the first international collaborative randomized blinded controlled trial in pediatric nephrology and one of the first in either pediatrics or nephrology. Increasing the number of large, important, and relevant clinical trials will require a culture shift within the nephrology community. Sep 9, 2021 · Background Globally, over 1. placebo, one of the pre-specified key secondary confirmatory endpoints. 3%). Saturday, October 26. We are continuing into the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists have been exceptional, leading to major advancements in the fast-growing field of Pediatrics. There was no significant difference in mortality at 90 days May 19, 2016 · In kidney transplantation, there is increasing recognition of the need to develop core outcomes spurring some efforts to review outcomes used in trials in kidney transplantation. Current renal impairment clinical research is focusing promisingly on several compounds including bardoxolone methyl, olmesartan medoxomil, sulodexide, and avosentan. Since the kidney is closely tied with many systems of the body it is important that it is working properly. 2MM+ Subscriber Exclusive Access: The Online Edition of The Classics Series™ includes The Classics in Medicine™ textbook and all deep-dive sub-specialty Some treatments have been assessed in randomized trials, but most such trials have been too small to … Despite the high costs of treatment of people with kidney disease and associated comorbid conditions, the amount of reliable information available to guide the care of such patients is very limited. In the Apr 19, 2021 · In a second trial, Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk (SCORED), a dual SGLT2 inhibitor and gastrointestinal SGLT1 inhibitor sotagliflozin was examined in patients with T2DM, CKD (eGFR from 25 to 60 mL/min/1. The data analysis of an RCT can be performed by using two complementary strategies, that is according to the intention to treat (ITT) principle and the per protocol (PP) analysis. Over the past few decades, several areas of medicine have conducted large-scale clinical trials with impactful changes in practice and patient-centric outcomes. Let’s review three important randomized trials below. The PIVOTAL trial investigated the use of intravenous iron to treat anaemia in dialysis patients, focusing on patient safety considerations. 47 The SONG Thursday, October 24 – Sunday, October 27. We performed this study to assess the absolute and relative importance of a range of cardiovascular outcomes based on the shared A deep understanding of these trials is paramount for every physician, healthcare professional, and trainee, as it lays the foundation for evidence-based clinical decisions made daily. Here we identified all randomized controlled trials in five nephrology and five general journals from 2005-2014. 8 for patients and caregivers/8. 95; p=0. A total of 74 articles met the inclusion criteria, Jan 25, 2024 · 1 in 7 American adults have chronic kidney disease (CKD); a disease that increases risk for CKD progression, cardiovascular events, and mortality. AURORA Trial (voclosporin) for Lupus Nephritis in The Lancet. 5 for health professionals, with 85%/95% rating it critically important, and top ranked on best–worst scale), followed by infection (mean 7. e. Jan 9, 2022 · 8. Optimizing trial design General trial design considerations. 4/8. Currently, the US Preventative Services Task Force does not have a screening recommendation, though evidence suggests that screening can prevent progression and is cost-effective. However, patient-important outcomes Oct 25, 2018 · Guidelines regarding the management of lipids in patients with chronic kidney disease (CKD) and especially in those with end-stage renal disease (ESRD) are inconsistent in part owing to important Jun 22, 2021 · To prevent the occurrence of cardiovascular events (CVEs), and end-stage kidney disease, achieving an optimal BP level is important. Conduct of Clinical Trials in Nephrology” in September 2016. The global Standardized Outcomes in Nephrology May 25, 2020 · ISN—Advancing Clinical Trials works to improve the clinical trials capacity of the global nephrology community through networking and training, and by standardizing high-quality trial conduct. We reviewed nephrology RCTs published in 13 nephrology and four general medical jour - nals between 1 July 2010 and 30 June 2011 (see Supplementary Methods and Supplementary Figure S1 online) to explore these domains. 6: Endothelin inhibition in Diabetic Nephropathy: SONAR in Lancet. Please contact us at landmarktrials@gmail. However, clinical trial data have consistently found no increase in risk of AKI or adverse outcomes of AKI with use of an SGLT2 inhibitor. Annual Meeting. This group provides a monthly inventory of important clinical trials, which is published on the ISN Academy website. A Clinical Scientist in Nephrology fellowship may be granted yearly, with a maximum duration of two years for each fellowship. For this trial, the ISKDC developed the criteria, such as those for response and relapse, used today to Jan 12, 2021 · Summary of trials, from the Landmark Nephrology RFN blog The single most important trial that revolutionized treatment, has been the 1984 trial ( Ponticelli et al , NEJM 1984)which established the role of alkylating agents (chlorambucil in this case) in the management of MN. Furthermore, prevention trials are important, because AKI after contrast and cardiac surgery significantly increases morbidity and mortality, particularly if RRT is required. 9% with a single study group, 64. At present, no s …. AKI is a common hospital complication associated with increased in-hospital and long-term mortality, extensive morbidity (including prolonged hospital length of stay), and an estimated annual cost of at least $10 billion in the United States. The concept of “reflux nephropathy” was born, whereby the VUR was considered the culprit, predisposing to recurrent UTIs and providing a conduit whereby the infection could ascend to the kidneys resulting in scarring and destruction New Clinical Trials for Nephrology. 1 Introduction. Phase 2: Larger trial of about 300 people to gather more Jun 22, 2020 · In most of these previous trials, renal function was diagnosed based on serum creatinine level or eGFR. Our study provides important feasibility data for an AKI stage-based, biomarker-guided interventional trial in AKI. May 20, 2022 · Through a consensus process involving over 1100 recipients, caregivers, and HCPs from 79 countries, the global Standardized Outcomes in Nephrology (SONG)-Tx initiative has established six core outcomes that should be reported in all kidney transplantation trials (Figure 1) (7, 8, 13). Jan 31, 2012 · A detailed discussion of the most important design elements for the conduct of a high-quality RCT is described in the text. For example, as one might expect, a relapse The analyses presented at the workshop provided important insight into which endpoints can be used in trials of earlier stages of CKD to predict a treatment’s effect on progression to kidney failure,” said Aliza Thompson, MD, MS, Clinical Team Leader in the Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Feb 3, 2022 · Given the alterations of renal function associated with the use of SGLT2 inhibitors, there has been ongoing caution regarding possible detrimental effects of these agents on the risk and prognosis of AKI. An important agency in the identification, evaluation, and synthesis Jan 7, 2020 · Will whole exome sequencing become standard of care for all patients with CKD? We’re entering a new era of genetic diagnosis in nephrology. A total of 127 randomized controlled trials reporting at least one dichotomous statistically significant outcome (p less than 0. S. Registration Closes. 411 patients were randomized at 39 centers in the United Kingdom. The majority of nephrology trials were for treatment (75. Nephrology is well positioned to harness such innovations due to its advanced use of electronic healthcare records An important focus of the division is to emphasize translational and multi-disciplinary programs that truly go from bedside to bench to bedside in advancing patient care solutions. Systematic reviews of observational studies have grown more common 1 day ago · This study aims to investigate the influencing factors of vascular calcification in peritoneal dialysis (PD) patients and its relationship with long-term prognosis. 73 m 2) and CV risk Nov 1, 2021 · The most recently completed Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial was a multinational, multicenter, open-label RCT that targeted 3,019 patients with severe AKI at 168 hospitals in 15 countries over a 4-year period. The discussions identified important trial design principles that are generic but inconsistently applied in trials among patients with kidney disease, as well as issues that are specific to such trials. , patients, caregivers, and health professionals). The WAK is a portable blood-based renal replacement device that is battery operated and can be worn like a belt or vest. The investigators deserve enormous credit for rigorously conducting trials that were logistically Mar 17, 2021 · The limited availability of randomized controlled trials (RCTs) in nephrology undermines causal inferences in meta-analyses. Late November. Phase 1: Small trial of 20-100 people why researchers observe the participants very closely, and check to see how the medicine or therapy works in a human body. Jun 27, 2016 · The AKIKI and ELAIN trials are important additions to the critical care nephrology literature. In a 2005–2010 study of ClinicalTrials. Populations at risk for CKD, such as those with hypertension in nephrology clinical research, which will only occur when a track record in trials and clinical research is regarded as equal to a track record in basic science for trainee nephrologists seeking a faculty position and for the promotion of senior nephrologists. of randomization reporting in clinical trials in nephrology. to help to ensure that nephrology trials are well designed More complete details are provided in the following. By using the ITT approach, investigators aim to assess the effect of assigning a drug whereas by adopting the PP analysis, researchers investigate the effect of Feb 20, 2021 · Standardized Outcomes in Nephrology (SONG) in children and adolescents has already published key patient-led outcomes for chronic kidney disease trials and this group would be an appropriate forum to determine what patients and their caregivers rank as the most important adverse effects of corticosteroids. g. NEJM 2022) was a multi-center, randomized, open-label trial that examined the impact of continuation of RAS inhibitors on the eGFR in advanced CKD G4-5. The maximum level of funding of $90,000 per year shall be used principally to support the candidate and his or her career development. Aug 31, 2023 · Glucocorticoid exposure remains a major contributor to morbidity and mortality in patients with immune-mediated kidney disease. Length: 28 weeks with treatment period over 24 weeks May 23, 2016 · Furthermore, larger trials are needed because small trials cannot avoid small baseline differences. Recently, there has been a paradigm shift in the management of BP largely as a result of the Systolic Blood Pressure Intervention Trial (SPRINT), which showed a reduction in CVEs by lowering systolic BP to 120 mmHg. CE/MOC Deadline. Wednesday, December 18. STAR 2009 The beginning of quality randomized clinical trials looking at RAS began in 2009. Kidney Week On-Demand Opens. 2023 was a big year for the nephrology (kidney) research field. Qianying Cao, Yanan Shi, Xiaohui Liu, Fan Yang, Xiangnan Li and Zhongxin Li. 3%), including 24. and 9. Recent findings: Analysis of renal outcome by estimating glomerular filtration rate in trials primarily devoted to cardiovascular protection in hypertensive patients, in particular the Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial trial, has come to question the effectiveness of suppressing the rennin-angiotensin Oct 25, 2022 · This device has been approved for trials in humans . vy nv at ly zk na fn aj um gq